CTLA4-Ig Effectively Controls Clinical Deterioration and Immune Condition in a Murine Model of Foxp3 Deficiency.

Gerbaux, Margaux; Roos, Evelyne; Willemsen, Mathijs; Staels, Frederik; Neumann, Julika; Bücken, Leoni; Haughton, Jeason; Yshii, Lidia; Dooley, James; Schlenner, Susan; Humblet-Baron, Stephanie; Liston, Adrian

Gerbaux, Margaux; Roos, Evelyne; Willemsen, Mathijs; Staels, Frederik; Neumann, Julika; Bücken, Leoni; Haughton, Jeason; Yshii, Lidia; Dooley, James; Schlenner, Susan; Humblet-Baron, Stephanie; Liston, Adrian.

Afiliação

Gerbaux M; KU Leuven, Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Roos E; Department of Medicine, Université Libre de Bruxelles, 1050, Brussels, Belgium.
Willemsen M; KU Leuven, Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Staels F; VIB Center for Brain and Disease Research, 3000, Louvain, Belgium.
Neumann J; KU Leuven, Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Bücken L; VIB Center for Brain and Disease Research, 3000, Louvain, Belgium.
Haughton J; KU Leuven, Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Yshii L; VIB Center for Brain and Disease Research, 3000, Louvain, Belgium.
Dooley J; KU Leuven, Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Schlenner S; VIB Center for Brain and Disease Research, 3000, Louvain, Belgium.
Humblet-Baron S; KU Leuven, Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Liston A; KU Leuven, Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.

J Clin Immunol ; 43(6): 1393-1402, 2023 08.

Article em En | MEDLINE | ID: mdl-37156988

Assuntos

Abatacepte; Deterioração Clínica; Doenças do Sistema Imunitário; Animais; Humanos; Camundongos; Abatacepte/uso terapêutico; Antígeno CTLA-4; Modelos Animais de Doenças; Fatores de Transcrição Forkhead/genética; Doenças do Sistema Imunitário/terapia; Sirolimo/farmacologia; Sirolimo/uso terapêutico; Linfócitos T Reguladores

Palavras-chave

FOXP3 deficiency; IPEX; Immunosuppressive treatment; Inborn error of immunity; Mouse model

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Abatacepte / Deterioração Clínica / Doenças do Sistema Imunitário Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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