Shared learning from a physiologically based pharmacokinetic modeling strategy for human pharmacokinetics prediction through retrospective analysis of Genentech compounds.

Mao, Jialin; Ma, Fang; Yu, Jesse; Bruyn, Tom De; Ning, Miaoran; Bowman, Christine; Chen, Yuan

Mao, Jialin; Ma, Fang; Yu, Jesse; Bruyn, Tom De; Ning, Miaoran; Bowman, Christine; Chen, Yuan.

Afiliação

Mao J; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Ma F; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Yu J; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Bruyn T; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Ning M; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Bowman C; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Chen Y; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.

Biopharm Drug Dispos ; 44(4): 315-334, 2023 Aug.

Article em En | MEDLINE | ID: mdl-37160730

Assuntos

Práticas Interdisciplinares; Humanos; Ratos; Camundongos; Animais; Cães; Estudos Retrospectivos; Macaca fascicularis; Modelos Biológicos; Área Sob a Curva; Farmacocinética

Palavras-chave

IVIVE; PBPK; human PK prediction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Práticas Interdisciplinares Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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