Overexpression of miR-4669 Enhances Tumor Aggressiveness and Generates an Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma: Its Clinical Value as a Predictive Biomarker.

Nakano, Toshiaki; Chen, Chao-Long; Chen, I-Hsuan; Tseng, Hui-Peng; Chiang, Kuei-Chen; Lai, Chia-Yun; Hsu, Li-Wen; Goto, Shigeru; Lin, Chih-Che; Cheng, Yu-Fan

Nakano, Toshiaki; Chen, Chao-Long; Chen, I-Hsuan; Tseng, Hui-Peng; Chiang, Kuei-Chen; Lai, Chia-Yun; Hsu, Li-Wen; Goto, Shigeru; Lin, Chih-Che; Cheng, Yu-Fan.

Afiliação

Nakano T; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
Chen CL; Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Chen IH; Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Tseng HP; Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Chiang KC; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
Lai CY; Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Hsu LW; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
Goto S; Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Lin CC; Liver Transplantation Center, Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Cheng YF; Liver Transplantation Center, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.

Int J Mol Sci ; 24(9)2023 Apr 26.

Article em En | MEDLINE | ID: mdl-37175615

Assuntos

Biomarcadores Tumorais; Carcinoma Hepatocelular; Exossomos; Neoplasias Hepáticas; MicroRNAs; Humanos; Biomarcadores Tumorais/genética; Carcinoma Hepatocelular/terapia; Carcinoma Hepatocelular/tratamento farmacológico; Linhagem Celular Tumoral; Proliferação de Células/genética; Exossomos/genética; Exossomos/patologia; Regulação Neoplásica da Expressão Gênica; Neoplasias Hepáticas/patologia; MicroRNAs/genética; Estudos Retrospectivos; Microambiente Tumoral/genética

Palavras-chave

GAPDH; drug resistance; exosomes; hepatocellular carcinoma; macrophage polarization; microRNAs; tumor cell migration; tumor microenvironment

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Carcinoma Hepatocelular / MicroRNAs / Exossomos / Neoplasias Hepáticas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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