Divergent Catalysis: Catalytic Asymmetric [4+2] Cycloaddition of Palladium Enolates.
J Am Chem Soc
; 145(20): 11301-11310, 2023 May 24.
Article
em En
| MEDLINE
| ID: mdl-37186945
ABSTRACT
An asymmetric decarboxylative [4+2] cycloaddition from a catalytically generated chiral Pd enolate was developed, forging four contiguous stereocenters in a single transformation. This was achieved through a strategy termed divergent catalysis, wherein departure from a known catalytic cycle enables novel reactivity of a targeted intermediate prior to re-entry into the original cycle. Mechanistic studies including quantum mechanics calculations, Eyring analysis, and KIE studies offer insight into the reaction mechanism.
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MEDLINE
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En
Ano de publicação:
2023
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Article