kcna1a mutant zebrafish model episodic ataxia type 1 (EA1) with epilepsy and show response to first-line therapy carbamazepine.

Dogra, Deepika; Meza-Santoscoy, Paola L; Gavrilovici, Cezar; Rehak, Renata; de la Hoz, Cristiane L R; Ibhazehiebo, Kingsley; Rho, Jong M; Kurrasch, Deborah M

Dogra, Deepika; Meza-Santoscoy, Paola L; Gavrilovici, Cezar; Rehak, Renata; de la Hoz, Cristiane L R; Ibhazehiebo, Kingsley; Rho, Jong M; Kurrasch, Deborah M.

Afiliação

Dogra D; Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada.
Meza-Santoscoy PL; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.
Gavrilovici C; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Rehak R; Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada.
de la Hoz CLR; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.
Ibhazehiebo K; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Rho JM; Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada.
Kurrasch DM; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.

Epilepsia ; 64(8): 2186-2199, 2023 08.

Article em En | MEDLINE | ID: mdl-37209379

Assuntos

Epilepsia; Peixe-Zebra; Humanos; Camundongos; Animais; Ataxia/tratamento farmacológico; Ataxia/genética; Ataxia/complicações; Convulsões/complicações; Carbamazepina/farmacologia; Carbamazepina/uso terapêutico; Canal de Potássio Kv1.1/genética

Palavras-chave

KCNA1; carbamazepine; epilepsy; episodic ataxia type 1; zebrafish

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Epilepsia Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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