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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Gong, Grace Q; Bilanges, Benoit; Allsop, Ben; Masson, Glenn R; Roberton, Victoria; Askwith, Trevor; Oxenford, Sally; Madsen, Ralitsa R; Conduit, Sarah E; Bellini, Dom; Fitzek, Martina; Collier, Matt; Najam, Osman; He, Zhenhe; Wahab, Ben; McLaughlin, Stephen H; Chan, A W Edith; Feierberg, Isabella; Madin, Andrew; Morelli, Daniele; Bhamra, Amandeep; Vinciauskaite, Vanesa; Anderson, Karen E; Surinova, Silvia; Pinotsis, Nikos; Lopez-Guadamillas, Elena; Wilcox, Matthew; Hooper, Alice; Patel, Chandni; Whitehead, Maria A; Bunney, Tom D; Stephens, Len R; Hawkins, Phillip T; Katan, Matilda; Yellon, Derek M; Davidson, Sean M; Smith, David M; Phillips, James B; Angell, Richard; Williams, Roger L; Vanhaesebroeck, Bart.
Afiliação
  • Gong GQ; Cell Signalling, Cancer Institute, University College London, London, UK.
  • Bilanges B; Cell Signalling, Cancer Institute, University College London, London, UK.
  • Allsop B; Drug Discovery Group, Translational Research Office, University College London, London, UK.
  • Masson GR; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
  • Roberton V; Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, UK.
  • Askwith T; UCL Centre for Nerve Engineering, UCL School of Pharmacy, University College London, London, UK.
  • Oxenford S; Drug Discovery Group, Translational Research Office, University College London, London, UK.
  • Madsen RR; Drug Discovery Group, Translational Research Office, University College London, London, UK.
  • Conduit SE; Cell Signalling, Cancer Institute, University College London, London, UK.
  • Bellini D; Cell Signalling, Cancer Institute, University College London, London, UK.
  • Fitzek M; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
  • Collier M; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Alderley Park, Macclesfield, UK.
  • Najam O; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Alderley Park, Macclesfield, UK.
  • He Z; The Hatter Cardiovascular Institute, University College London, London, UK.
  • Wahab B; The Hatter Cardiovascular Institute, University College London, London, UK.
  • McLaughlin SH; Medicines Discovery Institute, School of Biosciences, Cardiff University, Cardiff, UK.
  • Chan AWE; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
  • Feierberg I; Wolfson Institute for Biomedical Research, University College London, London, UK.
  • Madin A; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Waltham, MA, USA.
  • Morelli D; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Bhamra A; Cell Signalling, Cancer Institute, University College London, London, UK.
  • Vinciauskaite V; Proteomics Research Translational Technology Platform, Cancer Institute, University College London, London, UK.
  • Anderson KE; Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, UK.
  • Surinova S; Signalling Programme, Babraham Institute, Cambridge, UK.
  • Pinotsis N; Proteomics Research Translational Technology Platform, Cancer Institute, University College London, London, UK.
  • Lopez-Guadamillas E; Institute of Structural and Molecular Biology, Birkbeck College, London, UK.
  • Wilcox M; Cell Signalling, Cancer Institute, University College London, London, UK.
  • Hooper A; UCL Centre for Nerve Engineering, UCL School of Pharmacy, University College London, London, UK.
  • Patel C; Drug Discovery Group, Translational Research Office, University College London, London, UK.
  • Whitehead MA; Drug Discovery Group, Translational Research Office, University College London, London, UK.
  • Bunney TD; Cell Signalling, Cancer Institute, University College London, London, UK.
  • Stephens LR; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK.
  • Hawkins PT; Signalling Programme, Babraham Institute, Cambridge, UK.
  • Katan M; Signalling Programme, Babraham Institute, Cambridge, UK.
  • Yellon DM; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK.
  • Davidson SM; The Hatter Cardiovascular Institute, University College London, London, UK.
  • Smith DM; The Hatter Cardiovascular Institute, University College London, London, UK.
  • Phillips JB; Emerging Innovations, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Angell R; UCL Centre for Nerve Engineering, UCL School of Pharmacy, University College London, London, UK.
  • Williams RL; Drug Discovery Group, Translational Research Office, University College London, London, UK.
  • Vanhaesebroeck B; Medicines Discovery Institute, School of Biosciences, Cardiff University, Cardiff, UK.
Nature ; 618(7963): 159-168, 2023 Jun.
Article em En | MEDLINE | ID: mdl-37225977
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração Nervosa Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração Nervosa Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article