Your browser doesn't support javascript.
loading
Integrating contact tracing and whole-genome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study.
Lushasi, Kennedy; Brunker, Kirstyn; Rajeev, Malavika; Ferguson, Elaine A; Jaswant, Gurdeep; Baker, Laurie Louise; Biek, Roman; Changalucha, Joel; Cleaveland, Sarah; Czupryna, Anna; Fooks, Anthony R; Govella, Nicodemus J; Haydon, Daniel T; Johnson, Paul C D; Kazwala, Rudovick; Lembo, Tiziana; Marston, Denise; Masoud, Msanif; Maziku, Matthew; Mbunda, Eberhard; Mchau, Geofrey; Mohamed, Ally Z; Mpolya, Emmanuel; Ngeleja, Chanasa; Ng'habi, Kija; Nonga, Hezron; Omar, Kassim; Rysava, Kristyna; Sambo, Maganga; Sikana, Lwitiko; Steenson, Rachel; Hampson, Katie.
Afiliação
  • Lushasi K; Environmental Health and Ecological Sciences Department, Ifakara Health Institute, Dar es salaam, United Republic of Tanzania.
  • Brunker K; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Rajeev M; Department of Global Health and Biomedical Sciences, School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha, United Republic of Tanzania.
  • Ferguson EA; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Jaswant G; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, United States.
  • Baker LL; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Biek R; Environmental Health and Ecological Sciences Department, Ifakara Health Institute, Dar es salaam, United Republic of Tanzania.
  • Changalucha J; The University of Nairobi, Nairobi, Kenya.
  • Cleaveland S; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Czupryna A; College of the Atlantic, Bar Harbor, United States.
  • Fooks AR; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Govella NJ; Environmental Health and Ecological Sciences Department, Ifakara Health Institute, Dar es salaam, United Republic of Tanzania.
  • Haydon DT; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Johnson PCD; Animal & Plant Health Agency, Weybridge, United Kingdom.
  • Kazwala R; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Lembo T; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Marston D; Animal & Plant Health Agency, Weybridge, United Kingdom.
  • Masoud M; Environmental Health and Ecological Sciences Department, Ifakara Health Institute, Dar es salaam, United Republic of Tanzania.
  • Maziku M; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Mbunda E; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Mchau G; Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, United Republic of Tanzania.
  • Mohamed AZ; Boyd Orr Centre for Population and Ecosystem Health, School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.
  • Mpolya E; Animal & Plant Health Agency, Weybridge, United Kingdom.
  • Ngeleja C; Department of Comparative Biomedical Sciences, School of Veterinary Medicine, University of Surrey, Guildford, Surrey, United Kingdom.
  • Ng'habi K; Ministry for Health and Social Welfare, Zanzibar, United Republic of Tanzania.
  • Nonga H; Ministry of Livestock Development and Fisheries, Dodoma, United Republic of Tanzania.
  • Omar K; Ministry of Livestock Development and Fisheries, Dodoma, United Republic of Tanzania.
  • Rysava K; Department of Epidemiology, Ministry of Health, Community Development, Gender, Elderly and Children (MoHCDGEC), Dodoma, United Republic of Tanzania.
  • Sambo M; Department of Livestock Development, Pemba, Ministry of Livestock Development and Fisheries, Zanzibar, United Republic of Tanzania.
  • Sikana L; Department of Global Health and Biomedical Sciences, School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha, United Republic of Tanzania.
  • Steenson R; Tanzania Veterinary Laboratory Agency, Dar es salaam, United Republic of Tanzania.
  • Hampson K; Mbeya college of Health and Allied Sciences, University of Dar es Salaam, Mbeya, United Republic of Tanzania.
Elife ; 122023 05 25.
Article em En | MEDLINE | ID: mdl-37227428
Background: Dog-mediated rabies is endemic across Africa causing thousands of human deaths annually. A One Health approach to rabies is advocated, comprising emergency post-exposure vaccination of bite victims and mass dog vaccination to break the transmission cycle. However, the impacts and cost-effectiveness of these components are difficult to disentangle. Methods: We combined contact tracing with whole-genome sequencing to track rabies transmission in the animal reservoir and spillover risk to humans from 2010 to 2020, investigating how the components of a One Health approach reduced the disease burden and eliminated rabies from Pemba Island, Tanzania. With the resulting high-resolution spatiotemporal and genomic data, we inferred transmission chains and estimated case detection. Using a decision tree model, we quantified the public health burden and evaluated the impact and cost-effectiveness of interventions over a 10-year time horizon. Results: We resolved five transmission chains co-circulating on Pemba from 2010 that were all eliminated by May 2014. During this period, rabid dogs, human rabies exposures and deaths all progressively declined following initiation and improved implementation of annual islandwide dog vaccination. We identified two introductions to Pemba in late 2016 that seeded re-emergence after dog vaccination had lapsed. The ensuing outbreak was eliminated in October 2018 through reinstated islandwide dog vaccination. While post-exposure vaccines were projected to be highly cost-effective ($256 per death averted), only dog vaccination interrupts transmission. A combined One Health approach of routine annual dog vaccination together with free post-exposure vaccines for bite victims, rapidly eliminates rabies, is highly cost-effective ($1657 per death averted) and by maintaining rabies freedom prevents over 30 families from suffering traumatic rabid dog bites annually on Pemba island. Conclusions: A One Health approach underpinned by dog vaccination is an efficient, cost-effective, equitable, and feasible approach to rabies elimination, but needs scaling up across connected populations to sustain the benefits of elimination, as seen on Pemba, and for similar progress to be achieved elsewhere. Funding: Wellcome [207569/Z/17/Z, 095787/Z/11/Z, 103270/Z/13/Z], the UBS Optimus Foundation, the Department of Health and Human Services of the National Institutes of Health [R01AI141712] and the DELTAS Africa Initiative [Afrique One-ASPIRE/DEL-15-008] comprising a donor consortium of the African Academy of Sciences (AAS), Alliance for Accelerating Excellence in Science in Africa (AESA), the New Partnership for Africa's Development Planning and Coordinating (NEPAD) Agency, Wellcome [107753/A/15/Z], Royal Society of Tropical Medicine and Hygiene Small Grant 2017 [GR000892] and the UK government. The rabies elimination demonstration project from 2010-2015 was supported by the Bill & Melinda Gates Foundation [OPP49679]. Whole-genome sequencing was partially supported from APHA by funding from the UK Department for Environment, Food and Rural Affairs (Defra), Scottish government and Welsh government under projects SEV3500 and SE0421.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Raiva / Mordeduras e Picadas / Vacina Antirrábica / Doenças do Cão Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Animals / Humans País/Região como assunto: Africa Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Raiva / Mordeduras e Picadas / Vacina Antirrábica / Doenças do Cão Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Animals / Humans País/Região como assunto: Africa Idioma: En Ano de publicação: 2023 Tipo de documento: Article