PSEN1 E280A Cholinergic-like Neurons and Cerebral Spheroids Derived from Mesenchymal Stromal Cells and from Induced Pluripotent Stem Cells Are Neuropathologically Equivalent.

Mendivil-Perez, Miguel; Velez-Pardo, Carlos; Lopera, Francisco; Kosik, Kenneth S; Jimenez-Del-Rio, Marlene

Mendivil-Perez, Miguel; Velez-Pardo, Carlos; Lopera, Francisco; Kosik, Kenneth S; Jimenez-Del-Rio, Marlene.

Afiliação

Mendivil-Perez M; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), Calle 70 No. 52-21, Calle 62#52-59, Building 1, Room 412, SIU, Medellin 050010, Colombia.
Velez-Pardo C; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), Calle 70 No. 52-21, Calle 62#52-59, Building 1, Room 412, SIU, Medellin 050010, Colombia.
Lopera F; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), Calle 70 No. 52-21, Calle 62#52-59, Building 1, Room 412, SIU, Medellin 050010, Colombia.
Kosik KS; Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
Jimenez-Del-Rio M; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), Calle 70 No. 52-21, Calle 62#52-59, Building 1, Room 412, SIU, Medellin 050010, Colombia.

Int J Mol Sci ; 24(10)2023 May 18.

Article em En | MEDLINE | ID: mdl-37240306

Assuntos

Doença de Alzheimer; Células-Tronco Pluripotentes Induzidas; Células-Tronco Mesenquimais; Humanos; Células-Tronco Pluripotentes Induzidas/metabolismo; Doença de Alzheimer/metabolismo; Neurônios Colinérgicos/metabolismo; Células-Tronco Mesenquimais/metabolismo; Colinérgicos/metabolismo; Presenilina-1/genética; Presenilina-1/metabolismo

Palavras-chave

Alzheimer; E280a; apoptosis; iPSCs; mesenchymal stromal; mutant; presenilin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Células-Tronco Mesenquimais / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google