Identifying Novel Drug Targets for Epilepsy Through a Brain Transcriptome-Wide Association Study and Protein-Wide Association Study with Chemical-Gene-Interaction Analysis.

Lu, Mengnan; Feng, Ruoyang; Zhang, Chenglin; Xiao, Yanfeng; Yin, Chunyan

Lu, Mengnan; Feng, Ruoyang; Zhang, Chenglin; Xiao, Yanfeng; Yin, Chunyan.

Afiliação

Lu M; Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710054, Shanxi, China.
Feng R; Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, 710054, Shanxi, China.
Zhang C; Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710054, Shanxi, China.
Xiao Y; Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710054, Shanxi, China. xiaoyanfenggroup@sina.com.
Yin C; Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710054, Shanxi, China. yinchunyan0624@sina.com.

Mol Neurobiol ; 60(9): 5055-5066, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37246165

Assuntos

Epilepsia; Transcriptoma; Humanos; Transcriptoma/genética; Perfilação da Expressão Gênica/métodos; Estudo de Associação Genômica Ampla/métodos; Encéfalo; Epilepsia/genética; Predisposição Genética para Doença; Polimorfismo de Nucleotídeo Único; Proteínas do Citoesqueleto/genética; Peptídeos e Proteínas de Sinalização Intracelular/genética; Transativadores/genética

Palavras-chave

Chemical-related gene set enrichment analysis; Epilepsy; Human brain proteome; Proteome-wide association studies; Transcriptome-wide association studies

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epilepsia / Transcriptoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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