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P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma.
Sato, Kaname; Sano, Daisuke; Takahashi, Hideaki; Kuwahara, Tatsu; Aizawa, Yoshihiro; Aoyama, Jun; Nojima, Yusuke; Hatano, Takashi; Arai, Yasuhiro; Nishimura, Goshi; Hatakeyama, Hiromitsu; Oridate, Nobuhiko.
Afiliação
  • Sato K; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
  • Sano D; Department of Otolaryngology, Yokohama City University Medical Center, Yokohama, Japan.
  • Takahashi H; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan; dsano@yokohama-cu.ac.jp.
  • Kuwahara T; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
  • Aizawa Y; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
  • Aoyama J; Department of Otolaryngology, Yokohama City University Medical Center, Yokohama, Japan.
  • Nojima Y; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
  • Hatano T; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
  • Arai Y; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
  • Nishimura G; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
  • Hatakeyama H; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
  • Oridate N; Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Anticancer Res ; 43(6): 2571-2582, 2023 Jun.
Article em En | MEDLINE | ID: mdl-37247900
ABSTRACT
BACKGROUND/

AIM:

This study aimed to identify key molecules associated with the survival of patients with hypopharyngeal squamous cell carcinoma (HpSCC) by combining in silico and in vitro analyses. MATERIALS AND

METHODS:

Differentially expressed genes (DEGs) were screened using the Gene Expression Omnibus database. For DEGs, we performed functional enrichment and protein-protein interaction network analyses to identify potential biological functions and hub genes. Functional analysis of HpSCC cell lines verified the critical roles of the hub genes.

RESULTS:

DEGs were associated with the extracellular matrix. Among the hub genes, high expression of prolyl 4-hydroxylase subunit alpha 1 (P4HA1) was significantly associated with shorter survival. In addition, P4HA1 knockdown inhibited cell migration and colonization. Suppression of cell proliferation was demonstrated using P4HA1-selective inhibitors.

CONCLUSION:

P4HA1 may be a useful therapeutic target for the treatment of HpSCC.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mapas de Interação de Proteínas / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mapas de Interação de Proteínas / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article