Ultrasound-assessed lung aeration, oxygenation and respiratory care in neonatal bile acid pneumonia: A nested case-control study.
Acta Paediatr
; 112(9): 1898-1904, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37265415
ABSTRACT
AIM:
Neonatal bile acid pneumonia (NBAP) occurs in neonates following obstetric cholestasis. We aimed to study the lung aeration and respiratory support of NBAP.METHODS:
Nested, case/control study enrolling age-matched neonates with NBAP, respiratory distress syndrome (RDS) or transient tachypnoea (TTN). Lung aeration and oxygenation were assessed with lung ultrasound score, oxygenation index and SpO2 /FiO2 .RESULTS:
Nineteen, 22 and 25 neonates with NBAP, RDS and TTN, respectively were studied (mean gestational age = 33 (2.2) weeks, 30 (45.5%) males). Upon admission, RDS patients had the worst lung ultrasound score (p = 0.022) and oxygenation index (p = 0.001), while NBAP and TTN neonates had similar values. At the worst time-point, NBAP and RDS patients showed similar oxygenation index (NBAP 4.6 [2], RDS 5.7 [3]) and SpO2 /FiO2 (NBAP 3.1 [1.1], RDS 2.7 [1]) which were worse than those of TTN patients (oxygenation index p = 0.015, SpO2 /FiO2 p = 0.001). RDS neonates needed the longest continuous positive airway pressure and highest mean airway pressure, but NBAP neonates needed invasive ventilation (26.3%, p = 0.01) and surfactant (31.6%, p = 0.003) more often than TTN patients who never needed these.CONCLUSION:
NBAP was a mild disorder in the first hours of life but subsequently worsened and became similar to RDS.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia
/
Síndrome do Desconforto Respiratório do Recém-Nascido
/
Surfactantes Pulmonares
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article