Systematic conformation-to-phenotype mapping via limited deep sequencing of proteins.

Serebryany, Eugene; Zhao, Victor Y; Park, Kibum; Bitran, Amir; Trauger, Sunia A; Budnik, Bogdan; Shakhnovich, Eugene I

Serebryany, Eugene; Zhao, Victor Y; Park, Kibum; Bitran, Amir; Trauger, Sunia A; Budnik, Bogdan; Shakhnovich, Eugene I.

Afiliação

Serebryany E; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: evgeny_serebryany@fas.harvard.edu.
Zhao VY; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Park K; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Bitran A; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Trauger SA; Center for Mass Spectrometry, Harvard University, Cambridge, MA 02138, USA.
Budnik B; Center for Mass Spectrometry, Harvard University, Cambridge, MA 02138, USA.
Shakhnovich EI; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: shakhnovich@chemistry.harvard.edu.

Mol Cell ; 83(11): 1936-1952.e7, 2023 06 01.

Article em En | MEDLINE | ID: mdl-37267908

Assuntos

Proteínas de Escherichia coli; Dobramento de Proteína; Escherichia coli/genética; Escherichia coli/metabolismo; Conformação Proteica; Dissulfetos/metabolismo; Sequenciamento de Nucleotídeos em Larga Escala; Proteínas de Escherichia coli/genética; Proteínas de Escherichia coli/metabolismo

Palavras-chave

Chaperone; Conformational landscape; Disulfide bond; Disulfide scanning; Kinetic trap; Misfolding avoidance; Periplasm; Protein folding; Protein sequencing; Proteotoxic stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dobramento de Proteína / Proteínas de Escherichia coli Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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