Functional and structural characterization of Streptococcus pneumoniae pyruvate kinase involved in fosfomycin resistance.

Taguchi, Atsushi; Nakashima, Ryosuke; Nishino, Kunihiko

Taguchi, Atsushi; Nakashima, Ryosuke; Nishino, Kunihiko.

Afiliação

Taguchi A; SANKEN (The Institute of Scientific and Industrial Research), Osaka University, Ibaraki, Osaka, Japan; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan. Electronic address: taguchi@sanken.osaka-u.ac.jp.
Nakashima R; SANKEN (The Institute of Scientific and Industrial Research), Osaka University, Ibaraki, Osaka, Japan.
Nishino K; SANKEN (The Institute of Scientific and Industrial Research), Osaka University, Ibaraki, Osaka, Japan; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan. Electronic address: nishino@sanken.osaka-u.ac.jp.

J Biol Chem ; 299(7): 104892, 2023 07.

Article em En | MEDLINE | ID: mdl-37286036

Assuntos

Antibacterianos; Farmacorresistência Bacteriana; Fosfomicina; Piruvato Quinase; Streptococcus pneumoniae; Humanos; Antibacterianos/farmacologia; Fosfomicina/farmacologia; Cinética; Fosfoenolpiruvato/metabolismo; Piruvato Quinase/metabolismo; Streptococcus pneumoniae/efeitos dos fármacos; Streptococcus pneumoniae/enzimologia; Streptococcus pneumoniae/genética

Palavras-chave

Streptococcus; allosteric regulation; antibiotic resistance; enzyme kinetics; enzyme structure; fosfomycin; pyruvate kinase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Streptococcus pneumoniae / Farmacorresistência Bacteriana / Fosfomicina / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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