Sumatranins A-J: Lignans with Immunosuppressive Activity from Cleistanthus sumatranus.
J Nat Prod
; 86(6): 1606-1614, 2023 06 23.
Article
em En
| MEDLINE
| ID: mdl-37307145
ABSTRACT
Chemical investigation of the twigs of Cleistanthus sumatranus (Phyllanthaceae) led to the isolation of 10 undescribed lignans, sumatranins A-J (1-10). Compounds 1-4 are unprecedented furopyran lignans characterized by a unique 2,3,3a,9a-tetrahydro-4H-furo[2,3-b]chromene heterotricyclic framework. Compounds 9 and 10 are rare 9'-nor-dibenzylbutane lignans. Structures were established based on analyses of spectroscopic data, X-ray crystallographic data, and experimental ECD spectra. Immunosuppressive assays revealed compounds 3 and 9 displayed moderate inhibitory effects with good selectivity indexes against LPS-induced B lymphocyte proliferation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lignanas
/
Malpighiales
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article