Sulfoxides in medicine.
Curr Opin Chem Biol
; 76: 102340, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37307682
ABSTRACT
In the review, current status of sulfoxides on the pharmaceutical market is discussed. In the first part of the article, natural sulfoxides will be described with a special focus on sulforaphane and amanitin, a mushroom toxin which has been developed as payload in antibody drug conjugates in the possible cancer treatment. Controversies associated with the medical use of dimethylsulfoxide are briefly described in the next section. In the part devoted to PPIs, the benefits of using pure enantiomers (chiral switch) are discussed. An interesting approach, repositioning of drugs is exemplified by new possible applications of modafinil and sulindac. The review is concluded by presentation of cenicriviroc and adezmapimod, both with the status of promising drug candidates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfóxidos
/
Dimetil Sulfóxido
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article