C9orf72 poly-PR helps p53 escape from the ubiquitin-proteasome system and promotes its stability.

Yang, Fumin; Mahaman, Yacoubou Abdoul Razak; Zhang, Bin; Wang, Jian-Zhi; Liu, Rong; Liu, Fei; Wang, Xiaochuan

Yang, Fumin; Mahaman, Yacoubou Abdoul Razak; Zhang, Bin; Wang, Jian-Zhi; Liu, Rong; Liu, Fei; Wang, Xiaochuan.

Afiliação

Yang F; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Mahaman YAR; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang B; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang JZ; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liu R; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Liu F; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang X; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.

J Neurochem ; 166(2): 389-402, 2023 07.

Article em En | MEDLINE | ID: mdl-37319115

Assuntos

Esclerose Lateral Amiotrófica; Demência Frontotemporal; Humanos; Esclerose Lateral Amiotrófica/metabolismo; Complexo de Endopeptidases do Proteassoma/metabolismo; Demência Frontotemporal/genética; Demência Frontotemporal/metabolismo; Ubiquitina/metabolismo; Proteína C9orf72/genética; Proteína C9orf72/metabolismo; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Citoplasma/metabolismo; Dipeptídeos/genética; Expansão das Repetições de DNA

Palavras-chave

C9orf72 PR; FTD/ALS; mdm2; p53; ubiquition-proteasome pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência Frontotemporal / Esclerose Lateral Amiotrófica Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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