Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control.

Müller, Martin B D; Kasturi, Prasad; Jayaraj, Gopal G; Hartl, F Ulrich

Müller, Martin B D; Kasturi, Prasad; Jayaraj, Gopal G; Hartl, F Ulrich.

Afiliação

Müller MBD; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Kasturi P; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Jayaraj GG; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. Electronic address: jayaraj@biochem.mpg.de.
Hartl FU; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address: uhartl@biochem.mpg.de.

Cell ; 186(15): 3227-3244.e20, 2023 07 20.

Article em En | MEDLINE | ID: mdl-37339632

Assuntos

Biossíntese de Proteínas; Ribossomos; Animais; Ribossomos/metabolismo; Proteínas/metabolismo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Códon de Terminação/metabolismo; Mamíferos/metabolismo

Palavras-chave

BAG6 complex; CCR4/NOT; GCN1; aging; codon optimality; collagens; cotranslational mRNA decay; disomes; readthrough mitigation; transmembrane proteins

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ribossomos / Biossíntese de Proteínas Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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