Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients.
Platelets
; 34(1): 2226756, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37350057
What is the context? ⢠Evidence for an immune system dysfunction is reported in endometriosis and the association between endometriosis and autoimmune diseases is well known.⢠No autoimmune platelet function defect has been described so far.What is new?⢠We report two unrelated patients with endometriosis-associated infertility presenting a platelet glycoprotein VI deficiency due to an autoantibody.⢠In both cases, a deficient platelet aggregation response to collagen, convulxin or CRP and a severe GPVI deficiency were observed.⢠Immunoblot revealed no indication of GPVI cleavage.What is the impact? ⢠Our observation raises the question whether GPVI could be a preferential target for the development of anti-GPVI autoantibodies associated with endometriosis.⢠It does not seem that in these patients, GPVI deficiency is associated with an increased risk of severe bleeding disorder.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Endometriose
/
Infertilidade
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article