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The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis.
Carcel, Cheryl; Haghdoost, Faraidoon; Shen, Joanne; Nanda, Puneet; Bai, Yu; Atkins, Emily; Torii-Yoshimura, Takako; Clough, Alexander J; Davies, Leo; Cordato, Dennis; Griffiths, Lyn R; Balicki, Grace; Wang, Xia; Vidyasagar, Kota; Malavera, Alejandra; Anderson, Craig S; Zagami, Alessandro S; Delcourt, Candice; Rodgers, Anthony.
Afiliação
  • Carcel C; The George Institute for Global Health, , University of New South Wales, Sydney, Australia.
  • Haghdoost F; Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia.
  • Shen J; The George Institute for Global Health, , University of New South Wales, Sydney, Australia.
  • Nanda P; Faculty of Medicine and Health, The University of Sydney, Australia.
  • Bai Y; The George Institute for Global Health, , University of New South Wales, Sydney, Australia.
  • Atkins E; Peking Union Medical College, Beijing, China.
  • Torii-Yoshimura T; The George Institute for Global Health, , University of New South Wales, Sydney, Australia.
  • Clough AJ; The George Institute for Global Health, , University of New South Wales, Sydney, Australia.
  • Davies L; Faculty of Medicine and Health, The University of Sydney, Australia.
  • Cordato D; Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia.
  • Griffiths LR; Department of Neurology, Liverpool Hospital, Liverpool, Australia.
  • Balicki G; Centre for Genomics and Personalised Health, Queensland University of Technology, Queensland, Australia.
  • Wang X; The George Institute for Global Health, , University of New South Wales, Sydney, Australia.
  • Vidyasagar K; The George Institute for Global Health, , University of New South Wales, Sydney, Australia.
  • Malavera A; The George Institute India, Hyderabad, India.
  • Anderson CS; The George Institute for Global Health, , University of New South Wales, Sydney, Australia.
  • Zagami AS; The George Institute for Global Health, , University of New South Wales, Sydney, Australia.
  • Delcourt C; Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia.
  • Rodgers A; The George Institute China at Peking University Health Science Centre, Beijing, China.
Cephalalgia ; 43(6): 3331024231183166, 2023 06.
Article em En | MEDLINE | ID: mdl-37350141
ABSTRACT

BACKGROUND:

Currently, only a few specific blood pressure-lowering medications are recommended for migraine prevention. Whether benefits extend to other classes or drugs is uncertain.

METHODS:

Embase, MEDLINE, and the Cochrane Central Registry of Controlled Trials were searched for randomized control trials on the effect of blood pressure-lowering medications compared with placebo in participants with episodic migraine. Data were collected on four outcomes - monthly headache or migraine days, and monthly headache or migraine attacks, with a standardised mean difference calculated for overall. Random effect meta-analysis was performed.

RESULTS:

In total, 50 trials (70% of which were crossover) were included, comprising 60 comparisons. Overall mean age was 39 years, and 79% were female. Monthly headache days were fewer in all classes compared to placebo, and this was statistically significant for all but one class alpha-blockers -0.7 (95% CI -1.2, -0.1), angiotensin-converting enzyme inhibitors -1.3 (95% CI -2.9, 0.2), angiotensin II receptor blockers -0.9 (-1.6, -0.1), beta-blocker -0.4 (-0.8, -0.0) and calcium channel blockers -1.8 (-3.4, -0.2). Standardised mean difference was significantly reduced for all drug classes and was separately significant for numerous specific drugs clonidine, candesartan, atenolol, bisoprolol, metoprolol, propranolol, timolol, nicardipine and verapamil.

CONCLUSION:

Among people with episodic migraine, a broader number of blood pressure-lowering medication classes and drugs reduce headache frequency than those currently included in treatment guidelines.Trial Registration The study was registered at PROSPERO (CRD42017079176).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos de Enxaqueca Tipo de estudo: Clinical_trials / Guideline / Systematic_reviews Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos de Enxaqueca Tipo de estudo: Clinical_trials / Guideline / Systematic_reviews Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article