Development of On-DNA Cyclic Imide Synthesis for DNA Encoded Library Construction.
Chembiochem
; 24(18): e202300206, 2023 09 15.
Article
em En
| MEDLINE
| ID: mdl-37380609
ABSTRACT
Here, we describe a novel method for the on-DNA synthesis of cyclic imides, an important class of molecules that includes several well-known medications. Significantly, the new method enabled on-DNA synthesis under mild conditions with high conversions and a broad functional group tolerance, utilizing ubiquitous bifunctional amines and bis-carboxylic acid, or alkyl halides, and therefore served as the linchpin for DNA encoded library (DEL) synthesis. The mechanism study of off-DNA and on-DNA chemical transformations revealed unique insights in contrast to conventional chemical transformation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Imidas
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article