Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation.

Lentini, Germana; Famà, Agata; De Gaetano, Giuseppe Valerio; Coppolino, Francesco; Mahjoub, Ahlem Khachroub; Ryan, Liv; Lien, Egil; Espevik, Terje; Beninati, Concetta; Teti, Giuseppe

Lentini, Germana; Famà, Agata; De Gaetano, Giuseppe Valerio; Coppolino, Francesco; Mahjoub, Ahlem Khachroub; Ryan, Liv; Lien, Egil; Espevik, Terje; Beninati, Concetta; Teti, Giuseppe.

Afiliação

Lentini G; Department of Human Pathology, University of Messina, Messina, Italy.
Famà A; Department of Human Pathology, University of Messina, Messina, Italy.
De Gaetano GV; Department of Human Pathology, University of Messina, Messina, Italy; Scylla Biotech Srl, Messina, Italy.
Coppolino F; Department of Chemical, Biological and Pharmaceutical Sciences, University of Messina, Messina, Italy.
Mahjoub AK; Department of Human Pathology, University of Messina, Messina, Italy.
Ryan L; Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Lien E; Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Division of Infectious Diseases and Immunology, Program in Innate Immunity, Department of Medicine, University of Massachusetts Chan Med
Espevik T; Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Beninati C; Department of Human Pathology, University of Messina, Messina, Italy; Scylla Biotech Srl, Messina, Italy.
Teti G; Scylla Biotech Srl, Messina, Italy. Electronic address: gioteti@mac.com.

Cell Rep Med ; 4(7): 101098, 2023 07 18.

Article em En | MEDLINE | ID: mdl-37390829

Assuntos

Apoptose; Infecções Bacterianas; Animais; Camundongos; Infecções Bacterianas/tratamento farmacológico; Caspase 8/metabolismo; Caspase 8/farmacologia; Citocinas/metabolismo; Ativação de Neutrófilo

Palavras-chave

IFN-ß; Klebsiella pneumoniae; MLKL; RIPK1; RIPK3; antibiotic-resistant bacteria; caspase-1; group B streptococcus; pneumococcus

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Bacterianas / Apoptose Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google