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Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators.
Roopnarine, Osha; Yuen, Samantha L; Thompson, Andrew R; Roelike, Lauren N; Rebbeck, Robyn T; Bidwell, Philip A; Aldrich, Courtney C; Cornea, Razvan L; Thomas, David D.
Afiliação
  • Roopnarine O; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. roopn001@umn.edu.
  • Yuen SL; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Thompson AR; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Roelike LN; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Rebbeck RT; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Bidwell PA; Department of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Aldrich CC; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Cornea RL; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Thomas DD; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. ddt@umn.edu.
Sci Rep ; 13(1): 10673, 2023 07 01.
Article em En | MEDLINE | ID: mdl-37393380
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transferência Ressonante de Energia de Fluorescência / Insuficiência Cardíaca Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transferência Ressonante de Energia de Fluorescência / Insuficiência Cardíaca Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article