A DNA-encoded chemical library based on chiral 4-amino-proline enables stereospecific isozyme-selective protein recognition.

Oehler, Sebastian; Lucaroni, Laura; Migliorini, Francesca; Elsayed, Abdullah; Prati, Luca; Puglioli, Sara; Matasci, Mattia; Schira, Kristina; Scheuermann, Jörg; Yudin, Denis; Jia, Min; Ban, Nenad; Bushnell, Dave; Kornberg, Roger; Cazzamalli, Samuele; Neri, Dario; Favalli, Nicholas; Bassi, Gabriele.

Afiliação

Oehler S; Philochem AG, Otelfingen, Switzerland.
Lucaroni L; Philochem AG, Otelfingen, Switzerland.
Migliorini F; Philochem AG, Otelfingen, Switzerland.
Elsayed A; Philochem AG, Otelfingen, Switzerland.
Prati L; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland.
Puglioli S; Philochem AG, Otelfingen, Switzerland.
Matasci M; Philochem AG, Otelfingen, Switzerland.
Schira K; Philochem AG, Otelfingen, Switzerland.
Scheuermann J; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland.
Yudin D; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland.
Jia M; Institute of Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland.
Ban N; Institute of Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland.
Bushnell D; Institute of Molecular Biology and Biophysics, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland.
Kornberg R; NeoTX Therapeutics LTD, Stanford, CA, USA.
Cazzamalli S; NeoTX Therapeutics LTD, Stanford, CA, USA.
Neri D; Department of Structural Biology, Stanford University, Stanford, CA, USA.
Favalli N; Philochem AG, Otelfingen, Switzerland.
Bassi G; Philochem AG, Otelfingen, Switzerland.

Nat Chem ; 15(10): 1431-1443, 2023 Oct.

Article em En | MEDLINE | ID: mdl-37400597

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article