Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles.

Gao, Shenghua; Song, Letian; Cheng, Yusen; Zhao, Fabao; Kang, Dongwei; Song, Shu; Yang, Mianling; Ye, Bing; Zhao, Wei; Tang, Yajie; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng; Liu, Xinyong

Gao, Shenghua; Song, Letian; Cheng, Yusen; Zhao, Fabao; Kang, Dongwei; Song, Shu; Yang, Mianling; Ye, Bing; Zhao, Wei; Tang, Yajie; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng; Liu, Xinyong.

Afiliação

Gao S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
Song L; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Ji'nan 250012, China.
Cheng Y; Shenzhen Research Institute of Shandong University, A301 Virtual University Park in South District of Shenzhen, Shenzhen 518057, China.
Zhao F; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
Song S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
Yang M; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
Ye B; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Ji'nan 250012, China.
Zhao W; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
Tang Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
De Clercq E; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
Pannecouque C; State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Zhan P; State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Liu X; Rega Institute for Medical Research, K.U.Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium.