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Sex and APOE ε4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease.
Nemes, Sára; Logan, Paige E; Manchella, Mohit K; Mundada, Nidhi S; La Joie, Renaud; Polsinelli, Angelina J; Hammers, Dustin B; Koeppe, Robert A; Foroud, Tatiana M; Nudelman, Kelly N; Eloyan, Ani; Iaccarino, Leonardo; Dorsant-Ardón, Valérie; Taurone, Alexander; Thangarajah, Maryanne; Dage, Jeffery L; Aisen, Paul; Grinberg, Lea T; Jack, Clifford R; Kramer, Joel; Kukull, Walter A; Murray, Melissa E; Rumbaugh, Malia; Soleimani-Meigooni, David N; Toga, Arthur; Touroutoglou, Alexandra; Vemuri, Prashanthi; Atri, Alireza; Day, Gregory S; Duara, Ranjan; Graff-Radford, Neill R; Honig, Lawrence S; Jones, David T; Masdeu, Joseph; Mendez, Mario F; Musiek, Erik; Onyike, Chiadi U; Riddle, Meghan; Rogalski, Emily; Salloway, Stephen; Sha, Sharon J; Turner, Raymond S; Wingo, Thomas S; Womack, Kyle B; Wolk, David A; Rabinovici, Gil D; Carrillo, Maria C; Dickerson, Bradford C; Apostolova, Liana G.
Afiliação
  • Nemes S; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Logan PE; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Manchella MK; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Mundada NS; Department of Chemistry, University of Southern Indiana, Evansville, Indiana, USA.
  • La Joie R; Department of Neurology, University of California, San Francisco, California, USA.
  • Polsinelli AJ; Department of Neurology, University of California, San Francisco, California, USA.
  • Hammers DB; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Koeppe RA; Indiana Alzheimer's Disease Research Center, Indianapolis, Indiana, USA.
  • Foroud TM; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Nudelman KN; Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • Eloyan A; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Iaccarino L; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Dorsant-Ardón V; Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA.
  • Taurone A; Department of Neurology, University of California, San Francisco, California, USA.
  • Thangarajah M; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Dage JL; Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA.
  • Aisen P; Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA.
  • Grinberg LT; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Jack CR; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
  • Kramer J; Department of Neurology, University of California, San Francisco, California, USA.
  • Kukull WA; Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
  • Murray ME; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Rumbaugh M; Department of Neurology, University of California, San Francisco, California, USA.
  • Soleimani-Meigooni DN; Department of Epidemiology, University of Washington, Seattle, Washington, USA.
  • Toga A; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
  • Touroutoglou A; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Vemuri P; Department of Neurology, University of California, San Francisco, California, USA.
  • Atri A; Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, California, USA.
  • Day GS; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Duara R; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Graff-Radford NR; Banner Sun Health Research Institute, Sun City, Arizona, USA.
  • Honig LS; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
  • Jones DT; Department of Neurology, Center for Mind/Brain Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, Massachusetts, USA.
  • Masdeu J; Wein Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami, Florida, USA.
  • Mendez MF; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
  • Musiek E; Taub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
  • Onyike CU; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Riddle M; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Rogalski E; Nantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, Texas, USA.
  • Salloway S; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Sha SJ; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Turner RS; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Wingo TS; Department of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
  • Womack KB; Department of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Wolk DA; Department of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
  • Rabinovici GD; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
  • Carrillo MC; Department of Neurology, Georgetown Universit, Washington, District of Columbia, USA.
  • Dickerson BC; Department of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Apostolova LG; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Alzheimers Dement ; 19 Suppl 9: S49-S63, 2023 11.
Article em En | MEDLINE | ID: mdl-37496307
ABSTRACT

INTRODUCTION:

We used sex and apolipoprotein E ε4 (APOE ε4) carrier status as predictors of pathologic burden in early-onset Alzheimer's disease (EOAD).

METHODS:

We included baseline data from 77 cognitively normal (CN), 230 EOAD, and 70 EO non-Alzheimer's disease (EOnonAD) participants from the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS). We stratified each diagnostic group by males and females, then further subdivided each sex by APOE ε4 carrier status and compared imaging biomarkers in each stratification. Voxel-wise multiple linear regressions yielded statistical brain maps of gray matter density, amyloid, and tau PET burden.

RESULTS:

EOAD females had greater amyloid and tau PET burdens than males. EOAD female APOE ε4 non-carriers had greater amyloid PET burdens and greater gray matter atrophy than female ε4 carriers. EOnonAD female ε4 non-carriers also had greater gray matter atrophy than female ε4 carriers.

DISCUSSION:

The effects of sex and APOE ε4 must be considered when studying these populations. HIGHLIGHTS Novel analysis examining the effects of biological sex and apolipoprotein E ε4 (APOE Îµ4) carrier status on neuroimaging biomarkers among early-onset Alzheimer's disease (EOAD), early-onset non-AD (EOnonAD), and cognitively normal (CN) participants. Female sex is associated with greater pathology burden in the EOAD cohort compared to male sex. The effect of APOE ε4 carrier status on pathology burden was the most impactful in females across all cohorts.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article