Delayed ulceration following combination pulse dye laser and topical sirolimus treatment for port wine birthmarks: A case series.
Pediatr Dermatol
; 41(1): 108-111, 2024.
Article
em En
| MEDLINE
| ID: mdl-37571864
ABSTRACT
Port wine birthmarks (PWB) are capillary vascular malformations within the papillary and reticular dermis, most commonly occurring on the head and neck and may darken and thicken with age. Pulsed dye laser (PDL) is the gold standard of treatment for PWB as it selectively targets involved vessels. Sirolimus is a macrolide antibiotic that selectively inhibits mammalian target of rapamycin, thereby suppressing the angiogenesis pathways that can be activated by PDL. Sirolimus and PDL may be used together to treat PWB. We present a case series describing three cases of delayed ulceration and systemic sirolimus absorption following combination therapy, highlighting a potential complication and patient safety concern.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Capilares
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Mancha Vinho do Porto
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Malformações Vasculares
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Terapia a Laser
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Lasers de Corante
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article