IFNÉ£ but not IFN&#945; increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity.

Thomaidou, Sofia; Munoz Garcia, Amadeo; de Lange, Sabine; Gan, Jin; van der Slik, Arno R; Hoeben, Rob C; Roep, Bart O; Carlotti, Françoise; Zaldumbide, Arnaud

IFNÉ£ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity.

Thomaidou, Sofia; Munoz Garcia, Amadeo; de Lange, Sabine; Gan, Jin; van der Slik, Arno R; Hoeben, Rob C; Roep, Bart O; Carlotti, Françoise; Zaldumbide, Arnaud.

Afiliação

Thomaidou S; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. thomaidousofia@gmail.com.
Munoz Garcia A; Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
de Lange S; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Gan J; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
van der Slik AR; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Hoeben RC; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Roep BO; Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Carlotti F; Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Zaldumbide A; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. a.zaldumbide@lumc.nl.

Diabetologia ; 66(11): 2075-2086, 2023 11.

Article em En | MEDLINE | ID: mdl-37581620

Assuntos

Diabetes Mellitus Tipo 1; Células Secretoras de Insulina; Ilhotas Pancreáticas; Humanos; Insulina/metabolismo; Diabetes Mellitus Tipo 1/metabolismo; Autoimunidade; Ilhotas Pancreáticas/metabolismo; Interferon-alfa/farmacologia; Células Secretoras de Insulina/metabolismo; Interferon gama/farmacologia; Interferon gama/metabolismo

Palavras-chave

Autoantigens; Degradation; Inflammation; Proteasome; Type 1 diabetes

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Diabetes Mellitus Tipo 1 / Células Secretoras de Insulina Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google