Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers.
J Enzyme Inhib Med Chem
; 38(1): 2242714, 2023 Aug 17.
Article
em En
| MEDLINE
| ID: mdl-37592917
A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation of spirooxindoles and pyrimidines.In situ selenium nanoparticles (SeNPs) for some derivatives were synthesised.Cytotoxicity, Topo I and Topo II inhibitory assays, and DNA intercalation abilities were evaluated.Compound 7d NPs showed the best Topo I and Topo II inhibition.Cell cycle arrest, apoptosis induction, and molecular docking studies were performed.
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Base de dados:
MEDLINE
Assunto principal:
Selênio
/
Nanopartículas
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article