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Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition.
Park, Jung-Eun; Kirsch, Klara; Lee, Hobin; Oliva, Paola; Ahn, Jong Il; Ravishankar, Harsha; Zeng, Yan; Fox, Stephen D; Kirby, Samuel A; Badhwar, Pooja; Andresson, Thorkell; Jacobson, Kenneth A; Lee, Kyung S.
Afiliação
  • Park JE; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
  • Kirsch K; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
  • Lee H; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
  • Oliva P; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
  • Ahn JI; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
  • Ravishankar H; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
  • Zeng Y; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
  • Fox SD; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
  • Kirby SA; Protein Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
  • Badhwar P; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
  • Andresson T; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
  • Jacobson KA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.
  • Lee KS; Protein Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
Proc Natl Acad Sci U S A ; 120(35): e2305037120, 2023 08 29.
Article em En | MEDLINE | ID: mdl-37603740
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular Idioma: En Ano de publicação: 2023 Tipo de documento: Article