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Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection.
Selvavinayagam, Sivaprakasam T; Aswathy, Bijulal; Yong, Yean K; Frederick, Asha; Murali, Lakshmi; Kalaivani, Vasudevan; Jith, Karishma S; Rajeshkumar, Manivannan; Anusree, Adukkadukkam; Kannan, Meganathan; Gopalan, Natarajan; Vignesh, Ramachandran; Murugesan, Amudhan; Tan, Hong Yien; Zhang, Ying; Chandramathi, Samudi; Sivasankaran, Munusamy Ponnan; Govindaraj, Sakthivel; Byrareddy, Siddappa N; Velu, Vijayakumar; Larsson, Marie; Shankar, Esaki M; Raju, Sivadoss.
Afiliação
  • Selvavinayagam ST; State Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet 600 018, Chennai, Tamil Nadu, India.
  • Aswathy B; Infection and Inflammation, Department of Biotechnology, Central University of Tamil Nadu, Thiruvarur 610 005, India.
  • Yong YK; Laboratory Centre, Xiamen University Malaysia, 43 900 Sepang, Selangor, Malaysia.
  • Frederick A; National Tuberculosis Elimination Programme, Chennai, Tamil Nadu, India.
  • Murali L; National Tuberculosis Elimination Programme, Chennai, Tamil Nadu, India.
  • Kalaivani V; State Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet 600 018, Chennai, Tamil Nadu, India.
  • Jith KS; Infection and Inflammation, Department of Biotechnology, Central University of Tamil Nadu, Thiruvarur 610 005, India.
  • Rajeshkumar M; State Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet 600 018, Chennai, Tamil Nadu, India.
  • Anusree A; Blood and Vascular Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610 005, India.
  • Kannan M; Blood and Vascular Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610 005, India.
  • Gopalan N; Department of Epidemiology and Public Health, Central University of Tamil Nadu, Thiruvarur 610 005, India.
  • Vignesh R; Pre-clinical Department, Royal College of Medicine, Universiti Kuala Lumpur, Ipoh, Malaysia.
  • Murugesan A; Department of Microbiology, The Government Theni Medical College and Hospital, Theni, India.
  • Tan HY; Laboratory Centre, Xiamen University Malaysia, 43 900 Sepang, Selangor, Malaysia.
  • Zhang Y; Laboratory Centre, Xiamen University Malaysia, 43 900 Sepang, Selangor, Malaysia.
  • Chandramathi S; Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.
  • Sivasankaran MP; Seattle Children's Research Institute, Seattle, WA, USA.
  • Govindaraj S; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory Vaccine Center, Atlanta, GA, 30329, USA.
  • Byrareddy SN; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68131, USA.
  • Velu V; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory Vaccine Center, Atlanta, GA, 30329, USA.
  • Larsson M; Department of Biomedicine and Clinical Sciences, Linkoping University, 58 185 Linköping, Sweden.
  • Shankar EM; Infection and Inflammation, Department of Biotechnology, Central University of Tamil Nadu, Thiruvarur 610 005, India.
  • Raju S; State Public Health Laboratory, Directorate of Public Health and Preventive Medicine, DMS Campus, Teynampet 600 018, Chennai, Tamil Nadu, India.
medRxiv ; 2023 Aug 09.
Article em En | MEDLINE | ID: mdl-37609153
ABSTRACT

Background:

Early detection of latent tuberculosis infection (LTBI) is critical to TB elimination in the current WHO vision of End Tuberculosis Strategy.

Methods:

We investigated whether detecting plasma cytokines could aid in diagnosing LTBI across household contacts (HHCs) positive for IGRA, HHCs negative for IGRA, and healthy controls. We also measured the plasma cytokines using a commercial Bio-Plex Pro Human Cytokine 17-plex assay.

Results:

Increased plasma CXCL8 and decreased MCP-1, TNF-α, and IFN-γ were associated with LTBI. Regression analysis showed that a combination of CXCL8 and MCP-1 increased the risk of LTBI among HHCs to 14-fold.

Conclusions:

We postulated that CXCL8 and MCP-1 could be the surrogate biomarkers of LTBI, especially in resource-limited settings.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Screening_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Screening_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article