HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.
BMC Immunol
; 24(1): 25, 2023 08 29.
Article
em En
| MEDLINE
| ID: mdl-37644394
ABSTRACT
BACKGROUND:
Fishing communities surrounding Lake Victoria in Uganda have HIV prevalence of 28% and incidence rates of 5 per 100 person years. More than 50% of the local fishermen are infected with Schistosoma mansoni (S. mansoni). We investigated the role of S. mansoni coinfection as a possible modifier of immune responses against HIV. Using polychromatic flow cytometry and Gran-ToxiLux assays, HIV specific responses, T cell phenotypes, antibody-dependent cell-mediated cytotoxic (ADCC) potency and titres were compared between participants with HIV-S. mansoni coinfection and participants with HIV infection alone.RESULTS:
S. mansoni coinfection was associated with a modified pattern of anti-HIV responses, including lower frequency of bifunctional (IFNγ + IL-2 - TNF-α+) CD4 T cells, higher overall CD4 T cell activation and lower HIV ADCC antibody titres, compared to participants with HIV alone.CONCLUSIONS:
These results support the hypothesis that S. mansoni infection affects T cell and antibody responses to HIV in coinfected individuals.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esquistossomose
/
Infecções por HIV
/
Coinfecção
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article