Recovery of walking after paralysis by regenerating characterized neurons to their natural target region.
Science
; 381(6664): 1338-1345, 2023 09 22.
Article
em En
| MEDLINE
| ID: mdl-37733871
ABSTRACT
Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulations to their natural target regions remains unclear. To address this question, we applied projection-specific and comparative single-nucleus RNA sequencing to identify neuronal subpopulations that restore walking after incomplete SCI. We show that chemoattracting and guiding the transected axons of these neurons to their natural target region led to substantial recovery of walking after complete SCI in mice, whereas regeneration of axons simply across the lesion had no effect. Thus, reestablishing the natural projections of characterized neurons forms an essential part of axon regeneration strategies aimed at restoring lost neurological functions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paralisia
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Traumatismos da Medula Espinal
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Axônios
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Caminhada
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Recuperação de Função Fisiológica
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Regeneração Nervosa
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article