Ferrets as a Mammalian Model to Study Influenza Virus-Bacteria Interactions.
J Infect Dis
; 229(2): 608-615, 2024 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-37739789
ABSTRACT
Ferrets represent an invaluable model for the study of influenza virus pathogenicity and transmissibility. Ferrets are also employed for the study of bacterial pathogens that naturally infect humans at different anatomical sites. While viral and bacterial infection studies in isolation using animal models are important for furthering our understanding of pathogen biology and developing improved therapeutics, it is also critical to extend our knowledge to pathogen coinfections in vivo, to more closely examine interkingdom dynamics that may contribute to overall disease outcomes. We discuss how ferrets have been employed to study a diverse range of both influenza viruses and bacterial species and summarize key studies that have utilized the ferret model for primary influenza virus challenge followed by secondary bacterial infection. These copathogenesis studies have provided critical insight into the dynamic interplay between these pathogens, underscoring the utility of ferrets as a model system for investigating influenza virus-bacteria interactions.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Orthomyxoviridae
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Infecções Bacterianas
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Infecções por Orthomyxoviridae
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Influenza Humana
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article