An evolutionary history of F12 gene: Emergence, loss, and vulnerability with the environment as a driver.
Bioessays
; 45(12): e2300077, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37750435
ABSTRACT
In the context of macroevolutionary transitions, environmental changes prompted vertebrates already bearing genetic variations to undergo gradual adaptations resulting in profound anatomical, physiological, and behavioral adaptations. The emergence of new genes led to the genetic variation essential in metazoan evolution, just as was gene loss, both sources of genetic variation resulting in adaptive phenotypic diversity. In this context, F12-coding protein with defense and hemostatic roles emerged some 425 Mya, and it might have contributed in aquatic vertebrates to the transition from water-to-land. Conversely, the F12 loss in marine, air-breathing mammals like cetaceans has been associated with phenotypic adaptations in some terrestrial mammals in their transition to aquatic lifestyle. More recently, the advent of technological innovations in western lifestyle with blood-contacting devices and harmful environmental nanoparticles, has unfolded new roles of FXII. Environment operates as either a positive or a relaxed selective pressure on genes, and consequently genes are selected or lost. FXII, an old dog facing environmental novelties can learn new tricks and teach us new therapeutic avenues.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vertebrados
/
Cetáceos
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article