Does Media Choice Matter When Evaluating the Performance of Hydroxypropyl Methylcellulose Acetate Succinate-Based Amorphous Solid Dispersions?

Bapat, Pradnya; Paul, Shubhajit; Thakral, Naveen K; Tseng, Yin-Chao; Taylor, Lynne S

Bapat, Pradnya; Paul, Shubhajit; Thakral, Naveen K; Tseng, Yin-Chao; Taylor, Lynne S.

Afiliação

Bapat P; Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Paul S; Material and Analytical Sciences, Research and Development, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.
Thakral NK; Material and Analytical Sciences, Research and Development, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.
Tseng YC; Material and Analytical Sciences, Research and Development, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.
Taylor LS; Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.

Mol Pharm ; 20(11): 5714-5727, 2023 11 06.

Article em En | MEDLINE | ID: mdl-37751517

Assuntos

Metilcelulose; Polímeros; Solubilidade; Liberação Controlada de Fármacos; Metilcelulose/química; Polímeros/química; Indometacina; Ésteres; Água

Palavras-chave

amorphous solid dispersion; buffer capacity; dissolution mechanisms; pH-dependent solubility; release performance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Metilcelulose Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Metilcelulose Idioma: En Ano de publicação: 2023 Tipo de documento: Article