Exergy destruction in atrial fibrillation and a new 'Exergy Age Index'.

ABSTRACT

The concept of exergy in living organisms has been widely used to explore correlations between exergy and different physiological conditions. Atrial fibrillation (AF) is an abnormal physiological condition that takes place inside the heart and is recognised as a common supraventricular arrhythmia. AF can significantly undermine heart function and subsequently circulatory system. Thus, exergy analysis of cardiac flow during AF is a procedure to quantify the long-term impact of persistent AF. The present study adopts the lumped modelling approach for considering cardiovascular circulation and thermoregulation of the body to evaluate the exergy consumption and destruction of the heart in AF. In order to assess the impact of AF, four common AF-associated characteristics including lack of atrial kick, left atrial remodelling, left ventricular systolic dysfunction, and high-frequency fibrillation are examined. The results show that among AF deficiencies, high-frequency fibrillation is the main cause of exergy destruction of the heart during AF. Moreover, a novel 'exergy age index' is proposed which has shown that high fibrillatory conditions in AF can significantly accelerate the heart ageing process, which in turn substantiates AF's adverse impact on the heart.