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Glycine Decarboxylase (GLDC) Plays a Crucial Role in Regulating Energy Metabolism, Invasion, Metastasis and Immune Escape for Prostate Cancer.
Chen, Ming-Kun; Xiao, Zhuo-Yu; Huang, Zhi-Peng; Xue, Kang-Yi; Xia, Hui; Zhou, Jia-Wei; Liao, De-Ying; Liang, Zhi-Jian; Xie, Xiao; Wei, Qing-Zhu; Zhong, Lin; Yang, Jian-Kun; Liu, Cun-Dong; Liu, Yang; Zhao, Shan-Chao.
Afiliação
  • Chen MK; Department of Urology, NanFang Hospital, Southern Medical University, Guangzhou, 510515, China.
  • Xiao ZY; Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China.
  • Huang ZP; The Third Clinical College of Southern Medical University, Guangzhou, 510630, China.
  • Xue KY; Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China.
  • Xia H; The Third Clinical College of Southern Medical University, Guangzhou, 510630, China.
  • Zhou JW; Medical College of Shaoguan University, Shaoguan, 512026, China.
  • Liao DY; Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China.
  • Liang ZJ; The Third Clinical College of Southern Medical University, Guangzhou, 510630, China.
  • Xie X; Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China.
  • Wei QZ; The Third Clinical College of Southern Medical University, Guangzhou, 510630, China.
  • Zhong L; Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China.
  • Yang JK; The Third Clinical College of Southern Medical University, Guangzhou, 510630, China.
  • Liu CD; Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China.
  • Liu Y; The Third Clinical College of Southern Medical University, Guangzhou, 510630, China.
  • Zhao SC; Department of Urology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China.
Int J Biol Sci ; 19(15): 4726-4743, 2023.
Article em En | MEDLINE | ID: mdl-37781511
Glycine decarboxylase (GLDC) is one of the core enzymes for glycine metabolism, and its biological roles in prostate cancer (PCa) are unclear. First, we found that GLDC plays a central role in glycolysis in 540 TCGA PCa patients. Subsequently, a metabolomic microarray showed that GLDC enhanced aerobic glycolysis in PCa cells, and GLDC and its enzyme activity enhanced glucose uptake, lactate production and lactate dehydrogenase (LDH) activity in PCa cells. Next, we found that GLDC was highly expressed in PCa, was directly regulated by hypoxia-inducible factor (HIF1-α) and regulated downstream LDHA expression. In addition, GLDC and its enzyme activity showed a strong ability to promote the migration and invasion of PCa both in vivo and in vitro. Furthermore, we found that the GLDC-high group had a higher TP53 mutation frequency, lower CD8+ T-cell infiltration, higher immune checkpoint expression, and higher immune exclusion scores than the GLDC-low group. Finally, the GLDC-based prognostic risk model by applying LASSO Cox regression also showed good predictive power for the clinical characteristics and survival in PCa patients. This evidence indicates that GLDC plays crucial roles in glycolytic metabolism, invasion and metastasis, and immune escape in PCa, and it is a potential therapeutic target for prostate cancer.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Glicólise Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Glicólise Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article