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Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer.
Mohanty, Atish; Nam, Arin; Srivastava, Saumya; Jones, Jeff; Lomenick, Brett; Singhal, Sharad S; Guo, Linlin; Cho, Hyejin; Li, Aimin; Behal, Amita; Mirzapoiazova, Tamara; Massarelli, Erminia; Koczywas, Marianna; Arvanitis, Leonidas D; Walser, Tonya; Villaflor, Victoria; Hamilton, Stanley; Mambetsariev, Isa; Sattler, Martin; Nasser, Mohd W; Jain, Maneesh; Batra, Surinder K; Soldi, Raffaella; Sharma, Sunil; Fakih, Marwan; Mohanty, Saswat Kumar; Mainan, Avijit; Wu, Xiwei; Chen, Yihong; He, Yanan; Chou, Tsui-Fen; Roy, Susmita; Orban, John; Kulkarni, Prakash; Salgia, Ravi.
Afiliação
  • Mohanty A; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Nam A; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Srivastava S; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Jones J; Proteome Exploration Laboratory, California Institute of Technology, Pasadena, CA 91125, USA.
  • Lomenick B; Proteome Exploration Laboratory, California Institute of Technology, Pasadena, CA 91125, USA.
  • Singhal SS; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Guo L; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Cho H; Integrative Genomics Core, Beckman Research Institute, City of Hope, Monrovia, CA 91016, USA.
  • Li A; Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010,USA.
  • Behal A; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Mirzapoiazova T; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Massarelli E; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Koczywas M; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Arvanitis LD; Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010,USA.
  • Walser T; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Villaflor V; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Hamilton S; Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010,USA.
  • Mambetsariev I; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Sattler M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Nasser MW; Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • Jain M; Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • Batra SK; Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • Soldi R; Applied Cancer Research and Drug Discovery Division, Translational Genomics Research Institute (TGen) of City of Hope, Phoenix, AZ 850043, USA.
  • Sharma S; Applied Cancer Research and Drug Discovery Division, Translational Genomics Research Institute (TGen) of City of Hope, Phoenix, AZ 850043, USA.
  • Fakih M; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
  • Mohanty SK; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal 741246, India.
  • Mainan A; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal 741246, India.
  • Wu X; Integrative Genomics Core, Beckman Research Institute, City of Hope, Monrovia, CA 91016, USA.
  • Chen Y; W. M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
  • He Y; W. M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
  • Chou TF; Proteome Exploration Laboratory, California Institute of Technology, Pasadena, CA 91125, USA.
  • Roy S; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal 741246, India.
  • Orban J; W. M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
  • Kulkarni P; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
  • Salgia R; Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center, Duarte, CA 91010, USA.
Sci Adv ; 9(41): eade3816, 2023 10 13.
Article em En | MEDLINE | ID: mdl-37831779
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Resistencia a Medicamentos Antineoplásicos / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Resistencia a Medicamentos Antineoplásicos / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article