Neurodegenerative Disease Tauopathies.
Annu Rev Pathol
; 19: 345-370, 2024 Jan 24.
Article
em En
| MEDLINE
| ID: mdl-37832941
ABSTRACT
Tauopathies are a diverse group of progressive and fatal neurodegenerative diseases characterized by aberrant tau inclusions in the central nervous system. Tau protein forms pathologic fibrillar aggregates that are typically closely associated with neuronal cell death, leading to varied clinical phenotypes including dementia, movement disorders, and motor neuron disease. In this review, we describe the clinicopathologic features of tauopathies and highlight recent advances in understanding the mechanisms that lead to spread of pathologic aggregates through interconnected neuronal pathways. The cell-to-cell propagation of tauopathy is then linked to posttranslational modifications, tau fibril structural variants, and the breakdown of cellular protein quality control.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Neurodegenerativas
/
Tauopatias
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article