Maternal prenatal social experiences and offspring epigenetic age acceleration from birth to mid-childhood.
Ann Epidemiol
; 90: 28-34, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-37839726
ABSTRACT
PURPOSE:
Investigate associations of maternal social experiences with offspring epigenetic age acceleration (EAA) from birth through mid-childhood among 205 mother-offspring dyads of minoritized racial and ethnic groups.METHODS:
We used linear regression to examine associations of maternal experiences of racial bias or discrimination (0 = none, 1-2 = intermediate, or 3+ = high), social support (tertile 1 = low, 2 = intermediate, 3 = high), and socioeconomic status index (tertile 1 = low, 2 = intermediate, 3 = high) during the prenatal period with offspring EAA according to Horvath's Pan-Tissue, Horvath's Skin and Blood, and Intrinsic EAA clocks at birth, 3 years, and 7 years.RESULTS:
In comparison to children of women who did not experience any racial bias or discrimination, those whose mothers reported highest levels of racial bias or discrimination had lower Pan-Tissue clock EAA in early (-0.50 years; 90% CI -0.91, -0.09) and mid-childhood (-0.75 years; -1.41, -0.08). We observed similar associations for the Skin and Blood clock and Intrinsic EAA. Maternal experiences of discrimination were not associated with Pan-Tissue EAA at birth. Neither maternal social support nor socioeconomic status predicted offspring EAA.CONCLUSIONS:
Children whose mothers experienced higher racial bias or discrimination exhibited slower EAA. Future studies are warranted to confirm these findings and establish associations of early-life EAA with long-term health outcomes.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Epigênese Genética
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Mães
Limite:
Child
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Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article