Efficacy and Safety of Anti-Tumor Necrosis Factor Alpha in Very Early Onset Inflammatory Bowel Disease.

Collen, Lauren V; Mitsialis, Vanessa; Kim, David Y; Bresnahan, Mairead; Yang, Jessica; Tuthill, Margaret; Combs, Abigail; Barends, Jared; Field, Michael; Liu, Enju; Bearup, Richelle; Okoroafor, Ibeawuchi; Klein, Christoph; Muise, Aleixo M; Bousvaros, Athos; Ouahed, Jodie; Snapper, Scott B

Collen, Lauren V; Mitsialis, Vanessa; Kim, David Y; Bresnahan, Mairead; Yang, Jessica; Tuthill, Margaret; Combs, Abigail; Barends, Jared; Field, Michael; Liu, Enju; Bearup, Richelle; Okoroafor, Ibeawuchi; Klein, Christoph; Muise, Aleixo M; Bousvaros, Athos; Ouahed, Jodie; Snapper, Scott B.

Afiliação

Collen LV; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Mitsialis V; Division of Gastroenterology, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Kim DY; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Bresnahan M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Yang J; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Tuthill M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Combs A; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Barends J; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Field M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Liu E; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Bearup R; Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA, 02115, USA.
Okoroafor I; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Klein C; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Muise AM; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU Klinikum, and Gene Center, Ludwig Maximilians Universität München, Germany.
Bousvaros A; SickKids Inflammatory Bowel Disease Center, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Ouahed J; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Snapper SB; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

Inflamm Bowel Dis ; 2023 Oct 17.

Article em En | MEDLINE | ID: mdl-37847820

Half of VEOIBD patients followed for a median 5.8 years used anti-TNF. Anti-TNF failure occurred in half of those exposed. Stricturing, UC/IBD-U, and younger age at diagnosis were predictors of failure. Adverse events were similar to those reported in older patients.

Palavras-chave

adalimumab; infliximab; monogenic; very early onset inflammatory bowel disease; whole exome sequencing

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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