Genomic variation in neurons.
Dev Growth Differ
; 66(1): 35-42, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37855730
ABSTRACT
Neurons born during the fetal period have extreme longevity and survive until the death of the individual because the human brain has highly limited tissue regeneration. The brain is comprised of an enormous variety of neurons each exhibiting different morphological and physiological characteristics and recent studies have further reported variations in their genome including chromosomal abnormalities, copy number variations, and single nucleotide mutations. During the early stages of brain development, the increasing number of neurons generated at high speeds has been proposed to lead to chromosomal instability. Additionally, mutations in the neuronal genome can occur in the mature brain. This observed genomic mosaicism in the brain can be produced by multiple endogenous and environmental factors and careful analyses of these observed variations in the neuronal genome remain central for our understanding of the genetic basis of neurological disorders.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Variações do Número de Cópias de DNA
/
Mosaicismo
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article