PGT-HLA programmes for the cure of a sick sibling: clinical strategies for this challenging search.
Reprod Biomed Online
; 47(6): 103400, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37879124
ABSTRACT
The ultimate goal of a preimplantation genetic testing and human leukocyte antigen (PGT-HLA) matching programme is the birth of a healthy, HLA-compatible child for the treatment or cure of a sick sibling. Several authors have published successful cases of the births of children HLA-matched to siblings affected by different conditions and diseases. However, there are many reports of failed attempts. Couples seeking an HLA-matched sibling for their affected child look for positive outcomes in the shortest possible time. Nevertheless, there is no published consensus or guidelines with recommendations for these cases. Here, the authors aimed to analyse different approaches for these programmes, highlighting the most promising strategies for the families and fertility units. Furthermore, the authors mention a successful case of a PGT-HLA matching programme after a previous failed attempt following the strategies proposed. Which is the most cost-effective and time-efficient approach in a PGT-HLA matching programme?
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Diagnóstico Pré-Implantação
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Irmãos
Limite:
Child
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Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article