T-cell lymphocytes' aging clock: telomeres, telomerase and aging.
Biogerontology
; 25(2): 279-288, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37917220
ABSTRACT
Aging is the decline of physiological capabilities required for life maintenance and reproduction over time. The human immune cells, including T-cells lymphocytes, undergo dramatic aging-related changes, including those related to telomeres and telomerase. It was demonstrated that telomeres and telomerase play crucial roles in T-cell differentiation, aging, and diseases, including a well-documented link between short telomeres and telomerase activation demonstrated in several T-cells malignancies. Herein, we provide a comprehensive review of the literature regarding T-cells' telomeres and telomerase in health and age related-diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Telomerase
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article