TIM-3 expression induces resistance to PD-1 inhibitor in G-CSF-producing lung spindle cell carcinoma: A case report.

Hayashi, Fumiko; Akagi, Kazumasa; Taniguchi, Hirokazu; Matsutake, Toyoshi; Kawahara, Hiromi; Sekine, Ichiro; Gyotoku, Hiroshi; Takemoto, Shinnosuke; Soda, Hiroshi; Ashizawa, Kazuto; Mukae, Hiroshi

Hayashi, Fumiko; Akagi, Kazumasa; Taniguchi, Hirokazu; Matsutake, Toyoshi; Kawahara, Hiromi; Sekine, Ichiro; Gyotoku, Hiroshi; Takemoto, Shinnosuke; Soda, Hiroshi; Ashizawa, Kazuto; Mukae, Hiroshi.

Afiliação

Hayashi F; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Akagi K; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Taniguchi H; Clinical Oncology Center, Nagasaki University Hospital, Nagasaki, Japan.
Matsutake T; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Kawahara H; Clinical Oncology Center, Nagasaki University Hospital, Nagasaki, Japan.
Sekine I; Department of Respiratory Medicine, Kouseikai Hospital, Nagasaki, Japan.
Gyotoku H; Department of Internal Medicine, Kouseikai Hospital, Nagasaki, Japan.
Takemoto S; Department of Pathology, Kouseikai Hospital, Nagasaki, Japan.
Soda H; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Ashizawa K; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Mukae H; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.

Thorac Cancer ; 14(36): 3556-3560, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37926435

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Carcinoma; Neoplasias Pulmonares; Masculino; Humanos; Idoso de 80 Anos ou mais; Inibidores de Checkpoint Imunológico/uso terapêutico; Fator Estimulador de Colônias de Granulócitos/uso terapêutico; Receptor Celular 2 do Vírus da Hepatite A/uso terapêutico; Linfócitos T CD8-Positivos/metabolismo; Receptor de Morte Celular Programada 1/metabolismo; Carcinoma Pulmonar de Células não Pequenas/patologia; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/patologia; Pulmão/patologia; Antígeno B7-H1/metabolismo; Microambiente Tumoral

Palavras-chave

M2 macrophage; TIM-3; acquired resistance; immune checkpoint blockade; spindle cell carcinoma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Aged80 / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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