TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins.

Hayashi, Yuki; Takatori, Sho; Warsame, Waleed Y; Tomita, Taisuke; Fujisawa, Takao; Ichijo, Hidenori

Hayashi, Yuki; Takatori, Sho; Warsame, Waleed Y; Tomita, Taisuke; Fujisawa, Takao; Ichijo, Hidenori.

Afiliação

Hayashi Y; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Takatori S; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Warsame WY; Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Tomita T; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Fujisawa T; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Ichijo H; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

EMBO J ; 42(23): e114272, 2023 Dec 01.

Article em En | MEDLINE | ID: mdl-37929762

Assuntos

Autofagia; Proteínas de Membrana; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Lisossomos/metabolismo; Degradação Associada com o Retículo Endoplasmático; Retículo Endoplasmático/metabolismo

Palavras-chave

ER-phagy; TOLLIP; cargo adaptor; intrinsically disordered region; lysosome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Proteínas de Membrana Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Proteínas de Membrana Idioma: En Ano de publicação: 2023 Tipo de documento: Article