Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation.

Majumder, Suravi; Chattopadhyay, Abhijnan; Wright, Jamie M; Guan, Pujun; Buja, L Maximilian; Kwartler, Callie S; Milewicz, Dianna M

Majumder, Suravi; Chattopadhyay, Abhijnan; Wright, Jamie M; Guan, Pujun; Buja, L Maximilian; Kwartler, Callie S; Milewicz, Dianna M.

Afiliação

Majumder S; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, and.
Chattopadhyay A; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, and.
Wright JM; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, and.
Guan P; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, and.
Buja LM; Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Kwartler CS; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, and.
Milewicz DM; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, and.

JCI Insight ; 8(21)2023 Nov 08.

Article em En | MEDLINE | ID: mdl-37937642

Assuntos

Aterosclerose; Inibidores de Hidroximetilglutaril-CoA Redutases; Placa Aterosclerótica; Animais; Humanos; Camundongos; Aterosclerose/patologia; Colesterol/metabolismo; Miócitos de Músculo Liso/metabolismo; Placa Aterosclerótica/patologia

Palavras-chave

Atherosclerosis; Cell stress; Cholesterol; Genetics; Vascular Biology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Hidroximetilglutaril-CoA Redutases / Aterosclerose / Placa Aterosclerótica Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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