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Diazotization-Enabled Deaminative Late-Stage Functionalization of Primary Sulfonamides.
Li, Jiang-Sheng; Liu, Jia; Wang, Yao-Tian; Dai, Jia-Ying; Li, Zhi-Wei; Luo, Wei-Wei; Zhang, Yue-Fei; Liu, Han-Wen; Liu, Wei-Dong.
Afiliação
  • Li JS; Hunan Provincial Key Laboratory of CytoChemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China.
  • Liu J; Hunan Provincial Key Laboratory of CytoChemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China.
  • Wang YT; Hunan Provincial Key Laboratory of CytoChemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China.
  • Dai JY; Hunan Provincial Key Laboratory of CytoChemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China.
  • Li ZW; Hunan Provincial Key Laboratory of CytoChemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China.
  • Luo WW; Hunan Provincial Key Laboratory of CytoChemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China.
  • Zhang YF; Hunan Provincial Key Laboratory of CytoChemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China.
  • Liu HW; Hunan Provincial Key Laboratory of CytoChemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China.
  • Liu WD; National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry, Changsha 410007, China.
Org Lett ; 25(46): 8263-8268, 2023 Nov 24.
Article em En | MEDLINE | ID: mdl-37947421
ABSTRACT
We, for the first time, disclosed a simple and efficient strategy for the late-stage functionalization of primary sulfonamides by diazotization, leading to sulfonyl chlorides, sulfonates, and complex sulfonamides. This protocol obviates the requirement for the prefunctionalization of sulfonamides. Its applicability is exemplified by the late-stage functionalization of sulfonamide-type drugs.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article