CircFSCN1 induces tumor progression and triggers epithelial-mesenchymal transition in bladder cancer through augmentation of MDM2-mediated p53 silencing.

Deng, Wen; Chen, Ru; Xiong, Situ; Nie, Jianqiang; Yang, Hailang; Jiang, Ming; Hu, Bing; Liu, Xiaoqiang; Fu, Bin

Deng, Wen; Chen, Ru; Xiong, Situ; Nie, Jianqiang; Yang, Hailang; Jiang, Ming; Hu, Bing; Liu, Xiaoqiang; Fu, Bin.

Afiliação

Deng W; Department of Urology, the First Affiliated Hospital of Nanchang University, Yongwai street 17, Nanchang City 330006, China; Jiangxi Institute of Urology, Yongwai street 17, Nanchang City 330006, China.
Chen R; Department of Urology, the First Affiliated Hospital of Nanchang University, Yongwai street 17, Nanchang City 330006, China; Jiangxi Institute of Urology, Yongwai street 17, Nanchang City 330006, China; Department of Urology, Fujian Medical University Union Hospital, Fuzhou City 350001, China.
Xiong S; Department of Urology, the First Affiliated Hospital of Nanchang University, Yongwai street 17, Nanchang City 330006, China.
Nie J; Department of Urology, the First Affiliated Hospital of Nanchang University, Yongwai street 17, Nanchang City 330006, China.
Yang H; Department of Urology, the First Affiliated Hospital of Nanchang University, Yongwai street 17, Nanchang City 330006, China; Jiangxi Institute of Urology, Yongwai street 17, Nanchang City 330006, China.
Jiang M; Department of Urology, the First Affiliated Hospital of Nanchang University, Yongwai street 17, Nanchang City 330006, China; Jiangxi Institute of Urology, Yongwai street 17, Nanchang City 330006, China.
Hu B; Department of Urology, the First Affiliated Hospital of Nanchang University, Yongwai street 17, Nanchang City 330006, China; Jiangxi Institute of Urology, Yongwai street 17, Nanchang City 330006, China.
Liu X; Department of Urology, the First Affiliated Hospital of Nanchang University, Yongwai street 17, Nanchang City 330006, China; Jiangxi Institute of Urology, Yongwai street 17, Nanchang City 330006, China. Electronic address: shaw177@163.com.
Fu B; Department of Urology, the First Affiliated Hospital of Nanchang University, Yongwai street 17, Nanchang City 330006, China; Jiangxi Institute of Urology, Yongwai street 17, Nanchang City 330006, China. Electronic address: urofbin@163.com.

Cell Signal ; 114: 110982, 2024 02.

Article em En | MEDLINE | ID: mdl-37981069

Assuntos

Transição Epitelial-Mesenquimal; MicroRNAs; RNA Circular; Neoplasias da Bexiga Urinária; Humanos; Proteínas de Transporte/metabolismo; Linhagem Celular Tumoral; Movimento Celular/genética; Proliferação de Células/genética; Transição Epitelial-Mesenquimal/genética; Regulação Neoplásica da Expressão Gênica; Proteínas dos Microfilamentos/genética; Proteínas dos Microfilamentos/metabolismo; MicroRNAs/genética; MicroRNAs/metabolismo; Proteínas Proto-Oncogênicas c-mdm2/genética; Proteínas Proto-Oncogênicas c-mdm2/metabolismo; RNA Circular/genética; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Neoplasias da Bexiga Urinária/genética; Neoplasias da Bexiga Urinária/patologia

Palavras-chave

Bladder cancer; Epithelialmesenchymal transition; MDM2; circFSCN1; miR-145-5p; p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / MicroRNAs / Transição Epitelial-Mesenquimal / RNA Circular Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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