The evolutionary divergence of receptor guanylyl cyclase C has implications for preclinical models for receptor-directed therapeutics.

Mishra, Vishwas; Sharma, Kritica; Bose, Avipsa; Maisonneuve, Pierre; Visweswariah, Sandhya S

Mishra, Vishwas; Sharma, Kritica; Bose, Avipsa; Maisonneuve, Pierre; Visweswariah, Sandhya S.

Afiliação

Mishra V; Department of Developmental Biology and Genetics, Indian Institute of Science, Bengaluru, India.
Sharma K; Department of Developmental Biology and Genetics, Indian Institute of Science, Bengaluru, India.
Bose A; Department of Developmental Biology and Genetics, Indian Institute of Science, Bengaluru, India.
Maisonneuve P; UMR 5248 - Chemistry & Biology of Membranes and Nano-Objects, CNRS - Université de Bordeaux, Institut Européen de Chimie et Biologie, Pessac, France.
Visweswariah SS; Department of Developmental Biology and Genetics, Indian Institute of Science, Bengaluru, India. Electronic address: sandhya@iisc.ac.in.

J Biol Chem ; 300(1): 105505, 2024 Jan.

Article em En | MEDLINE | ID: mdl-38029963

Assuntos

Receptores Acoplados a Guanilato Ciclase; Animais; Criança; Humanos; Camundongos; Diarreia; Enterotoxinas; Guanilato Ciclase/metabolismo; Ligantes; Receptores de Enterotoxina/genética; Receptores Acoplados a Guanilato Ciclase/antagonistas & inibidores; Receptores Acoplados a Guanilato Ciclase/genética; Receptores Acoplados a Guanilato Ciclase/metabolismo; Gastroenteropatias/tratamento farmacológico; Gastroenteropatias/metabolismo; Gastroenteropatias/patologia

Palavras-chave

bacterial toxin; cGMP; guanylin; guanylyl cyclase; kinase; ligand; linaclotide; plecanatide; receptor guanylyl cyclase C; uroguanylin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Acoplados a Guanilato Ciclase Limite: Animals / Child / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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